Scientific Programme

1st Day – 16th October 2019 (Wednesday)

Hours

Event / Venues

08:30-12:00

Registration

12:00-14:00

Lunch

Room

Hall A

Hall B

14:00-16:30

CEC-1
Use of Biomarkers in Human Biomonitoring

CEC-2

Recent Developments and The Use of Non-Invasive Samples in Comet Assay

Chair

 

 

14:00-14:30

Biomarkers of Exposure and Early Biological Effects

Stefano BONASSI (Italy)

The Use of the Best Biomarker from the Best (Non-Invasive) Tissue

Sabine LANGIE (Belgium)

14:30-15:00

Study Design in Molecular Epidemiology

Stefano BONASSI (Italy)

The Use of Different Blood Cell Preparations in the Comet Assay

Andrew COLLINS (Norway)

15:00-15:30

Statistical Analysis of Human Studies with Biomarkers

Stefano BONASSI (Italy)

The Use of Buccal Cells in Human Biomonitoring and Early Disease

Mirta MILIĆ (Crotia)

15:30-16:00

Designing a Biomonitoring Study: Practical Exercise

Stefano BONASSI (Italy)

Confounding Factors Affecting Comet Assay Results in Human Biomonitoring Studies

Amaia AZQUETA (Spain )

16:00-16:30

DNA Damage-Based Biomarkers in Cancer Measured by Mass Spectometry

Erdem COŞKUN (USA)

A Comparison of DNA Damage Levels, Assessed in Placental Tissue and Umbilical Cord Blood (NEOGENE project)

Carla COSTA (Portugal)

16:30-17:00

Coffee Break

17:00-17:15

Opening Ceremony

17:15-17:45

Opening Lecture

Toxicology From the Perspectives of a Journal Editor

Hermann BOLT (Germany)

17:45-19:00

Welcome reception

19:30-21:30

Dinner

2nd Day – 17th October 2019 (Thursday)

09:00-09:30

Plenary Lecture

State of Science of the Risk Assessment of Nanomaterials

Mary GULUMIAN (South Africa)

09:30-10:00

Coffee Break

Session I (10:00-12:30) – Recent Data on Carcinogenicity Studies

Room

Hall A

Chair

 

10:00-10:30

Carcinogenicity Studies-Overview of Guidelines, Hanan GHANTOUS (USA)

10:30-11:00

Carcinogenicity Studies and Status of ICHS1 and Implications, Owen Mc MASTER (USA)

11:00-11:30

Carcinogenicity of Immune Modulators, Kenneth HASTINGS (USA)

11:30-12:00

Biomarkers of Cancer Risk, Stefano BONASSI (Italy)

12:00-12:30

DNA Repair in Cancer Therapy, Miral DİZDAROĞLU (USA)

12:30-14:00

Lunch

Session II (14:00-16:10)

Applicability and Limitation of Non-Animal Testing in Safety Assessment

Session III (14:00-16:30)

Use of Comet Assay in Biomonitoring of DNA Damage in Different Settings

Room

Hall A

Hall B

Chair

 

 

14:00-14:30

Regulatory Use of Non Animal Models: Limitations and Pitfalls

Emanuela TESTAI (Italy)

Genomic Damage in Obesity and after Weight Loss

Helga STOPPER (Germany)

14:30-15:00

History of a Success: Contact Hypersensitivity

Emanuela CORSINI (Italy)

Plant Comet Assay in Environmental Studies

Bertrand POURRUT (France)

15:00-15:30

Future Perspectives of in Non-Animal Models

Thomas HARTUNG (USA)

The Importance of Individual Susceptibility on the Levels of DNA Damage: the Case of Styrene-Exposed Workers

Joao Paulo TEXEIRA (Portugal)

15:30-16:00

The Use of Organ-on-a-chip Technologies in Toxicological Research

Sebastiaan TRIETSCH (The Netherlands)

The Comet Assay Testing Nanomaterials in Advanced in Vitro Models

Maria DUSINSKA (Slovakia)

16:00-16:10

Applicability of Toxicological Data in Health Based Exposure Limits

Semra ŞARDAŞ (Turkey)

The Effects of Storage Conditions in Comet Assay in Human Blood and Lymphocytes

Merve BACANLI (Turkey)

16:10-16:20

Genotoxicity and Oxidative Lipid Damage Under Occupational Pesticide Exposure

Elisa BOUTET-ROBINET (France)

16:20-16:30

The Genotoxic Potential of Water Samples from the Rivers Drenica and Sitnica (Kosovo) in Primary Rat Hepatocytes as Assessed by the Comet and the Micronucleus Assay

Avdulla ALIJA (Kosovo)

16:30-17:00

Coffee Break

Exhibitor-Hosted Workshop (17:00-19:00)

Room

Hall A

17:00-19:00

From Automatic Image Capture to Publication-Ready Data. Augmented Microscopy(TM) with BioTek Imaging Systems.

Hüseyin TUNCAY, ANT TEKNİK-BIOTEK

Short Presentations – I

Biomonitoring Studies in Different Settings

Short Presentations – II

Safety of Metals / Metal Containing Nanoparticles

Short Presentations – III

Clinical Toxicology

Room

Hall A

Hall B

Hall C

Chair

 

 

 

17:00-17:15

Defining Experimental Conditions for Using GH2AX Assay in Biomonitoring Studies

Vanessa Valdiglesias (Spain)

Evaluation of Biosafety of Nanoparticles, TiO2 and Fe3O4, Commonly Used in Nanomedicine

Yüksel Çetin (Turkey)

Chlorine Gas Inhalation: A Case Report

Eren Gökdağ (Turkey)

17:15-17:30

Induction of Chromosomal Damage in Exfoliated Buccal Cells and Nasal Cells of Road Stripe Painters

Georg Wultsch (Austria)

Silver but not Gold Nanoparticles Attenuate Tumor Growth and Metastasis in BALB/c Mice

Marcin Kruszewski (Poland)

Carbamazepine Intoxication: A Case Report

Yücel Yüzbaşıoğlu (Turkey)

17:30-17:40

The Impact of Boat Pressure-Washing: Toxicology and Solutions

Marko Gerić (Croatia)

In Vitro Genotoxicity Assessment of Silver Sulfide Quantum Dots Coated with Meso-2,3-Dimercaptosuccinic Acid by Micronucleus Assay

Gökçe Taner (Turkey)

Alba strawberry extract attenuates endogenous oxidative stress in Alzheimer`s patients

Biljana Spremo-Potparevica (Serbia)

17:40-17-50

Evaluation of the Cyto/Genotoxic Effects of Marine Toxin Domoic Acid in Non-Target Human Cells in Vitro

Goran Gajski (Croatia)

Effects of Apoptosis-Inducing 2-Mercaptopropionic Acid (2-MPA)-Coated Silver Sulfide QD on Human A549 Cells

Deniz Özkan Vardar (Turkey)

Evaluation of Therapeutical Potential of Novel Indole Derivatives in Estrogen- Induced Breast Carcinogenesis

Elif İnce (Turkey)

17:50-18:00

Reconstructed Human Small Intestine Tissue Model for Drug Toxicity and Permeability Screening in Vitro

Jan Markus (Slovakia)

Evaluation of Cytotoxic Effect Mechanisms of ZnO and CuO Nanoparticles Individually or as a Mixture in Mouse Fibroblast Cells and Protective Effects of DTPA, NAC or Taurine

Duygu Paslı (Turkey)

Analysis and Correlation of Addictive Substances at Postmortem Nasal Swabs and Hair Samples

Erkin Kırkpınar (Turkey)

18:00-18:10

Differences Between Biochemical and DNA Damage Parameters (comet Assay and Micronucleus assay) Before and After Three Weeks of Interventional Hypocaloric Diet in Obese Patients Monitored in the Special Hospital for Extended Treatment of Duga Resa, Croatia – Preliminary Results

Mirta Milić (Crotia)

Bifenthrin-induced Neurological Alterations and Anxiety-like Behavior in Adult Rats

Hamadi Fetoui (Tunusia)

Cardiotoxicity Induced by Tyrosine Kinase Inhibitors

Ayşenur Günaydın (Turkey)

18:10-18:20

Differential Expression of Peroxisome Proliferator-Activated Receptors in Hepatic and Testicular Tissues in Bisphenol A Exposed Mice

Sheikh Raisuddin (India)

Activity of Hawthorn on Reproductive Markers of Wistar Rat under Copper Intoxication

Cherif Abdennour (Algeria)

Assessment of Heavy Metals in Medicinal Plants

Hakan Özden (Turkey)

18:20-18:30

Amelioration of Incision Wound Healing by Scorzonera Veratrifolia Extract in Rats: Evaluation of Oxidative Stress and Genotoxic Effect

Ayfer Beceren (Turkey)

Determination of Blood Heavy Metal Levels in the Residents of Gemikonagi and Tepebasi and Evaluation of Associated Genotoxic Effects

Kumsal Kocadal (TRNC)

Manganese intoxication due to torpedo explosion

Sultan Pınar Çetintepe (Turkey)

18:30-18:40

Investigation of Genotoxic Potential of Diflucortolone and Derivatives in Silico for Risk Assessment

Gülçin Tuğcu (Turkey)

Evaluation of Heavy Metal Concentrations in Sediments and Vegetables Obtained from Gemikonağı and Yenierenköy in Northern Cyprus

Fehmi Burak Alkaş (TRNC)

Organic UV Filters in Cosmetics and Breast Milk

Selma YAZAR (Turkey)

18:40-18:50

Promoter Genome-Wide Analysis of Histone Modifications and Drugs Targeting Epigenetic Alterations in Breast Cancer

Seher Karsli-Ceppioglu (Turkey)

The Heavy Metal, Solvent And Polyaromntic Hydrocarbon Pattern In Ceramic Workers

Meşide Gündüzöz (Turkey)

18:50-19:20

Poster Viewing

3rd Day – 18th October 2019 (Friday)

09:00-09:30

Plenary Lecture

Human Health Protection Through Chemical Stewardship – An Industry Perspective

Salmaan H. INAYAT-HUSSAIN (Malaysia)

09:30-09:30

Coffee Break

Session IV (10:00-12:30)

Food Safety

Session V (10:00-12:30)

Organ Spesific Toxic Reactions and Related Adverse Outcome Pathways

Room

Hall A

Hall B

Chair

 

 

10:00-10:30

The Importance of Risk Communication in Food Safety

Martin WILKS (Switzerland)

Contribution of Mitochondria to Clozapine-Induced Cardiotoxicity and Paracetamol-Induced Hepatotoxicity

Hilmi ORHAN (Turkey)

10:30-11:00

Procedures of Risk Assessment in Food Safety in Turkey

Serap HANCI (Turkey)

Adverse Outcome Pathways Associated with Mitochondria

Mathieu VINKEN (Belgium)

11:00-11:30

The Reproductive Toxicity of Mycotoxins

Hassan MALEKINEJAD (Iran)

Adverse Drug Reactions: Molecular Mechanisms and Inter-Individual Differences

Nico P.E. VERMEULEN (The Netherlands)

11:30-12:00

PFOS and PFOA in Food: Main Conclusions of the EFSA 2018 Risk Assessment

Tanja SCHWERDTLE (Germany)

Influence of Epigenetic Mechanisms in Kidney Toxicity: Ochratoxin A and Fumonisins

Sibel ÖZDEN (Turkey)

12:00-12:30

Nutraceuticals :Aspects of Efficacy and Toxicity in the Genomic Era

Marco RACCHI (Italy)

The Search for an Optimal Human Liver Line for the Detection of Mutagens

Siegfried KNASMUELLER (Austria )

12:30-14:00

Lunch

Session VI (14:00-16:30)

Emerging Enviromental Issues

Session VII (14:00-16:30)

Endocrine Disrupting Effects of Chemicals and Pharmaceuticals – Their Role in Diseases

Room

Hall A

Hall B

Chair

 

 

14:00-14:30

Immunotoxicity of PFAS as Drinking Water, Food and Occupational Contaminants

Emanuela CORSINI (Italy)

Nonclinical Evaluation of Endocrine-Related Drug Toxicity: Experiences with Novel Drug Candidates and Herbal Dietary Supplements

Hande GURER-ORHAN (Turkey)

14:30-15:00

Human Health Effects of Cyanotoxins

Emanuela TESTAI (Italy)

FDA CLARITY-BPA (The Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity) Study: Safety Assessments and Non-Monotonic Dose Response

Neslihan AYGUN-KOCABAS (Belgium)

15:00-15:30

Biomonitoring of the General Population Living Near the Waste-to-Energy Incinerator of Turin, Italy: Serum Concentrations of Organic Pollutants of Major Concern after Some Years from the Plant Start-up

Elena DE FELIP (Italy)

Towards a Harmonized Integrated Assessment of Metabolism Disrupting Compounds (The GOLIATH Project)

Jorke KAMSTRA (The Netherlands)

15:30-16:00

Microplastics: Are They Really a Threat?

Emanuela TESTAI (Italy), Jennifer DE FRANCE (WHO)

Role of Endocrine Disruptors in Various Pathological Conditions: A Special Focus on Phthalates, Bisphenols and Polychlorinated Biphenyls

Pınar ERKEKOGLU (Turkey)

16:00-16:10

Studies of Chemical Mixtures from Real Exposure to in Vitro

Carina LADEIRA (Portugal)

Adverse Effects of Psychoactive Drugs on Sperm Parameters: The Role of the Hypothalamic-Pituitary-Gonadal Axis

Sinem ILGIN ( Turkey)

16:10-16:20

Simultaneous Determination of 24-Elements in Some Herbal Teas Consumed in Turkey: A Brief Toxicological and Chemometric View

İ. İpek BOŞGELMEZ (Turkey)

16:20-16:30

Analysis of Deoxynivalenol (Vomitoxin) in Cereal Based Baby Foods by HPLC

Mücteba EŞREF TATLIPINAR (Turkey)

16:30-17:00

Coffee Break

Exhibitor-Hosted Workshop (17:00-19:00)

Room

Hall A

Chair

 

17:00-19:00

In Vitro Reconstructed 3D Models for the Safety Assessment of Chemicals, Cosmetics, Drugs and Medical Devices

MatTek

Short Presentations IV

Cytotoxic and Genotoxic Effects of Chemicals

Short Presentations V

Recent Toxicological Studies in Turkey

Room

Hall A

Hall B

Chair

 

 

17:00-17:10

Domoic acid as a Marine Toxine from Mussels

Goran Gajski (Croatia)

Alterations Observed in the Histone Modifications on P16 Gene Caused by Fumonisin B1 in Human Kidney Cells

Ecem Fatma Karaman (Turkey)

17:10-17:20

Effects of the 1,4-Dihydropyridine Salts Assessed In Vitro and In Vivo

Nikolajs Sjakste (Latvia)

The Toxic Effects of Acetamiprid on Reproductive System: Subchronic Study on Male Rats

Yağmur Emre Arıcan (Turkey)

17:20-17:30

Evaluation of Genotoxic Effects of Spherical and Rod-Shaped Nano-Hydroxyapatites in Drosophila Melanogaster

Merve Güneş (Turkey)

How Safe are the ADI Values for Food Additives? (A Novel Zebrafish Modelling for Evaluating the Toxicity of Food Additives)

Saltuk Buğrahan Ceyhun (Turkey)

17:30-17:40

Evaluation of The Cytotoxic and Genotoxic Effects of Pitavastatin in Cervical Cancer Cell Line

Aysun Ökçesiz (Turkey)

Acetamiprid Induced Oxidative Damage and Apoptosis in SH-SY5Y Cell Line

Ezgi Öztaş (Turkey)

17:40-17:50

Evaluation of Cytotoxic, Genotoxic and Apoptotic Effects of Flurbiprofen in Human Liver Cancer Cell Line

Elçin Bakır (Turkey)

In Vitro Apoptotic and Oxidative Stress Evaluation of Benomyl in SH-SY5Y Cell Line

Mehtap Kara (Turkey)

17:50-18:00

Possible Cytotoxic Effects and Molecular Mechanisms of Tamoxifen and Quinazoline Derivatives Doxazosin, Erlotinib on Endometrial Cancer Cells

Ayşe Eken (Turkey)

Evaluation of Neuroendocrine Disrupting Effects of Prenatal Exposure to Bisphenol A and/or Di(2-ethylhexyl) Phthalate

Anıl Yirun (Turkey)

18:00-18:10

Usefulness of RTL-W1 Cell Lines as an Alternative to Animal Testing in the Monitoring the Toxic Substances in Aquatic Environments

Ozge Cemiloglu Ulker (Turkey)

Evaluation of Toxic Effects of Dibutyl Phthalate on A549 Cells and Possible Protective Effects of Ascorbic Acid and N-Acetylcysteine

Aylin Balcı (Turkey)

18:10-18:20

In Vitro Investigation of Cytotoxic Effects and DNA Damage of Bisphenol Analogs Compared to Bisphenol A

İrem İyigündoğdu (Turkey)

In Vitro Evaluation of Blood-Brain Barrier Penetration by PLGA and PEG-b-PLGA Nanoparticles Loaded with Obidoxime

Sermet Sezigen (Turkey)

18:20-18:30

Helicobacter Pylori Infection Causes Both DNA Single and Double Strand Breaks and Oxidative Stress in Human Adenocarcinoma Cell Line

Didem Oral (Turkey)

Tetrahydrobiyopterin Dependent Nitric Oxide and Neopterin Levels in Guanosine Triphosphate Pathway in Gestational Diabetes Mellitus

Songül Ünüvar (Turkey)

18:30-18:40

The anticancer activity of cinnamaldehyde toward U87MG cells and its synergistic effect on doxorubicin’s anticancer activity

Leila Hosseinzadeh (Iran)

Modeling of de- and Remyelination in 3D Brain Spheres

Sevcan Gül Akgün-Ölmez (Turkey)

18:40-18:50

In Vitro Safety Assessment of Four Different Ganoderma lucidum Products Purchased Online

Tuğçe Yeşil Devecioğlu (Turkey)

Computational Toxicology: From Bench-Based Toxicology to Computational-Based Risk Assessment

Esra Emerce (Turkey)

18:50-19:00

In Vitro Evaluation Of Toxin Binding Efficacy For Aflatoxinb1, Ochratoxin A, Citrinin, Zearalenone, T2 Toxin, Penicillic Acid And Fumonisin In Broiler Feed

Sarathchandra Ghadevaru (India)

The Role of Insulin on CYP1A1 and CYP2E1 Activities and Lipid Peroxidation Levels in Streptozotocin-Induced Diabetic Rats in Liver

Gökçe Kuzgun (Turkey)

19:00-19:10

In Vitro Toxicity and In Vivo Bioaccumulation Potency of Lys-graft-p(HEMA) Polymeric Nanoparticles

N. Ulku Karabay Yavasoglu (Turkey)

Lead Content of Lipsticks in Turkish Cosmetic Market and Assessment of Their Health Risks

Onur Kenan Ulutaş (Turkey)

20:00-24:00

Gala Dinner

4th Day – 19th October 2019 (Saturday)

09:00-09:30

Plenary Lecture

Late Effects of Chronic Pesticide Exposure in Humans

Mohammad ABDOLLAHI (Iran)

09:00-09:30

Coffee Break

Session VIII (10:00-12:00)

Occurence, Use and Potential Toxic Effects of Metals

Session IX (10:00-12:00)

Lipidomics

Room

Hall A

Hall B

Chair

 

 

10:00-10:30

Toxicity of Arsenic Species: Lessons from Cells, Flies , Worms, Mice and Humans

Tanja SCHWERDETLE (Germany)

Impact of Oxysterols on the Peroxisome: Physiopathological Consequences

Gerard LIZARD (France)

10:30-11:00

Reproductive and Developmental Effects of Boron in Humans Under Occupational and / or Environmental Exposure Conditions

Yalçın DUYDU (Turkey)

Cholesterol and Related Sterol Autoxidation

Luigi LULIANO (Italy)

11:00-11:30

Cadmium Impact on Increased Risk of Osteoporosis

Vesna MATOVIĆ (Serbia)

Use of Tandem Mass Spectrometry in Polyunsaturated Fatty Acid and Sphingolipid Measurements

Mutay ASLAN (Turkey)

11:30-12:00

Toxicological Properties of Metal-Based Nanoparticles: What Makes the Difference?

Andrea HARTWIG (Germany)

Lipidomic Research in Toxicology

Suna SABUNCUOGLU (Turkey)

12:00-12:30

Closing Ceremony